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  • BioBioPha
  • China
  • Product Name: Fumaric acid
  • Price: ¥Inquiry/5mg
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Xueping-Zheng



110-17-8

110-17-8 structure
110-17-8 structure

Name fumaric acid
Synonyms U-1149
FEMA 2488
FUMARSAEURE
but-2-en-1,4-dioic acid
TMEDA
trans-2-Butenedioic Acid
Fumarsure
trans-butenedioic acid
Fumaric acid
fumaric
EINECS 203-743-0
MFCD00002700
Boletic acid
Description Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8.

Density 1.5±0.1 g/cm3
Boiling Point 355.5±25.0 °C at 760 mmHg
Melting Point 298-300 °C (subl.)(lit.)
Molecular Formula C4H4O4
Molecular Weight 116.072
Flash Point 183.0±19.7 °C
Exact Mass 116.010956
PSA 74.60000
LogP -0.01
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.526
Stability Stable at room temperature. Decomposes at around 230 C. Incompatible with strong oxidizing agents, bases, reducing agents. Combustible.
Water Solubility 0.63 g/100 mL (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LS9625000
CHEMICAL NAME :
Fumaric acid
CAS REGISTRY NUMBER :
110-17-8
BEILSTEIN REFERENCE NO. :
0605763
LAST UPDATED :
199710
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C4-H4-O4
MOLECULAR WEIGHT :
116.08
WISWESSER LINE NOTATION :
QV1U1VQ -T

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
587 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes Liver - other changes Blood - hemorrhage
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6800 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
40 mg/kg
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 77,750,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 33940 No. of Facilities: 2317 (estimated) No. of Industries: 27 No. of Occupations: 44 No. of Employees: 30637 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 33940 No. of Facilities: 5692 (estimated) No. of Industries: 40 No. of Occupations: 58 No. of Employees: 136448 (estimated) No. of Female Employees: 48919 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36
Safety Phrases S26
RIDADR UN 9126
WGK Germany 1
RTECS LS9625000
HS Code 2942000000
HS Code 2942000000