Shanghai Nianxing Industrial Co., Ltd
China
Product Name: D-erythro-Sphingosine
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Purity: 99.0%
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GL Biochem (Shanghai) Ltd.
China
Product Name: D-Sphingosine
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Purity: 98.0%
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Sphingosine
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Purity: 98.9%
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DC Chemicals Limited
China
Product Name: Sphingosine
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-aminooctadec-4-ene-1,3-diol
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Purity: 98.0%
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123-78-4

123-78-4 structure

123-78-4 structure

Name: D-erythro-Sphingosine
Chemical Name: sphingosine
CAS Number: 123-78-4
Molecular Formula: C₁₈H₃₇NO₂
Molecular Weight: 299.492
Catalog: Natural Products Others
Create Date: 2018-02-28 08:00:00
Modify Date: 2024-01-03 05:29:34
D-erythro-Sphingosine is a very potent activator of p32-kinase with an EC50 of 8 μM. D-erythro-Sphingosine inhibits protein kinase C (PKC).

Name	sphingosine
Synonyms	EINECS 204-651-3 (4E)-sphing-4-enine D-erythro-Sphingosine,synthetical BRAIN,BOVINE MFCD00036751 Sphingosine, D-erythro DErySphingosine [3H]-Sphingosine 4-trans-Sphingenine Sphingosine 4-Sphingenine [Fluorescein]-Sphingosine (2S,3R,4E)-2-Aminooctadec-4-ene-1,3-diol Sphingenine EGG SPHINGOSINE D-erythro-Sphingosine D-Sphingosine 4-Octadecene-1,3-diol, 2-amino-, (2S,3R,4E)- erythro-4-Sphingenine CEREBROSIDE (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol (-)-D-erythro-Sphingosine (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-ene-1-ol BRAIN SPHINGOSINE (4E)-sphingenine trans-4-sphingenine D-erythrosphingosine C18-Sphingosine (2S,3R,E)-2-Amino-4-octadecene-1,3-diol Sphingosine 2S,3R,2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol UNII:0Y6SVQ612Q (4E)-2-Aminooctadec-4-ene-1,3-diol

Description	D-erythro-Sphingosine is a very potent activator of p32-kinase with an EC50 of 8 μM. D-erythro-Sphingosine inhibits protein kinase C (PKC).
Related Catalog	Research Areas >> Cancer Natural Products >> Others
Target	p32:8 μM (EC50) PKC Human Endogenous Metabolite
In Vitro	A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines[1]. D-erythro-Sphingosine inhibits protein kinase C in vitro[2]. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells[3].
References	[1]. Pushkareva MYu, et al. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid basesand inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15;294 ( Pt 3):699-703. [2]. Khan WA, et al. Protein kinase C and platelet inhibition by D-erythro-Sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. Biochem Biophys Res Commun. 1990 Oct 30;172(2):683-91. [3]. Pham VT, et al. A concise synthesis of a promising protein kinase C inhibitor: D-erythro-Sphingosine. Arch Pharm Res. 2007 Jan;30(1):22-7.

Density	0.9±0.1 g/cm3
Boiling Point	445.9±45.0 °C at 760 mmHg
Melting Point	81-82ºC
Molecular Formula	C₁₈H₃₇NO₂
Molecular Weight	299.492
Flash Point	223.5±28.7 °C
Exact Mass	299.282440
PSA	66.48000
LogP	6.40
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.489
Water Solubility	chloroform: 20 mg/mL

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2922199090

Precursor 7
116467-63-1 572922-39-5 105308-75-6 103348-49-8
115464-03-4 1094213-80-5 511542-07-7
DownStream 10
10575-28-7 3102-57-6 123-78-4 26993-30-6
544-63-8 638-53-9 54164-50-0 764-22-7
74713-60-3 74713-59-0

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%