18968-99-5

18968-99-5 structure

18968-99-5 structure

Name: MAGNESIUM PEMOLINE
Chemical Name: magnesium,2-amino-5-phenyl-1,3-oxazol-4-one,dihydroxide
CAS Number: 18968-99-5
Molecular Formula: C₉H₁₀MgN₂O₄
Molecular Weight: 234.49200
Create Date: 2018-09-12 15:16:35
Modify Date: 2024-01-11 11:46:16

Name	magnesium,2-amino-5-phenyl-1,3-oxazol-4-one,dihydroxide
Synonyms	Pemoline magnesium chelate 2-Amino-5-phenyl-2-oxazolin-4-one + Mg(OH)2 Magnesium pemoline Pemoline magnesium Pemoline magnesium hydroxide mixture Tamilan Pemoline magnesium hydroxide Pemolin and magnesium hydroxide DEA No. 1530

Boiling Point	313.6ºC at 760 mmHg
Molecular Formula	C₉H₁₀MgN₂O₄
Molecular Weight	234.49200
Flash Point	143.4ºC
Exact Mass	234.04900
PSA	105.14000
LogP	0.38150

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RY1105000

CHEMICAL NAME :: Pemoline magnesium

CAS REGISTRY NUMBER :: 18968-99-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H10-Mg-N2-O4

MOLECULAR WEIGHT :: 234.52

WISWESSER LINE NOTATION :: T5OYMV EHJ BUM ER &-MG-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 149 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Gastrointestinal - nausea or vomiting

REFERENCE :: CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 18,761,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 485 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,810,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - irritability Lungs, Thorax, or Respiration - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 181,441,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 487 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 181,441,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - changes in motor activity (specific assay) Skin and Appendages - hair

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 181,441,1969