175553-48-7

175553-48-7 structure

Name: (2S)-(+)-1-BENZOYL-2-TERT-BUTYL-3-METHYL-4-IMIDAZOLIDINONE
Chemical Name: 1-(6-amino-5-oxooctan-4-yl)-2,3-dihydroindole-2-carboxamide,oxalate
CAS Number: 175553-48-7
Molecular Formula: C₁₉H₂₇N₃O₆
Molecular Weight: 393.43400
Catalog: Research Areas Neurological Disease
Create Date: 2018-12-04 17:48:47
Modify Date: 2024-01-02 12:16:50
Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation[1][2].

Name	1-(6-amino-5-oxooctan-4-yl)-2,3-dihydroindole-2-carboxamide,oxalate

Description	Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 7 nM (TPP II) and 10 μM (TPP I)[1]
In Vitro	Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) inhibits TPP II activity of cerebral membranes[2].
In Vivo	Butabindide (UCL-1397; 10 mg/kg; i.v.; for 20 min) inhibits the breakdown of CCK-8 in the gastrointestinal tract and increases satiety in mice[2]. Animal Model: Mice (25-30 g) Dosage: 10 mg/kg Administration: Intravenous injection; for 20 minutes Result: Reduces food intake and elicits other behavioral concomitants of satiation.
References	[1]. Ganellin CR, et, al. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. J Med Chem. 2005 Nov 17;48(23):7333-42. [2]. Rose C, et, al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 1996 Apr 4;380(6573):403-9.