201010-95-9

201010-95-9 structure

Name: ER-27319
Chemical Name: 3,4-Dimethyl-10-(3-aminopropyl)-9-acridone oxalate
CAS Number: 201010-95-9
Molecular Formula: C₂₀H₂₂N₂O₅
Molecular Weight: 370.40
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Syk
Create Date: 2017-08-20 01:24:28
Modify Date: 2024-01-11 21:43:30
ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM and can be used for study in allergic diseases[1][2].

Name	3,4-Dimethyl-10-(3-aminopropyl)-9-acridone oxalate
Synonyms	3,4-Hexanediol,3,4-dimethyl-1,6-diphenyl 3,4-dimethyl-1,6-diphenyl-3,4-hexanediol

Description	ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM and can be used for study in allergic diseases[1][2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk Research Areas >> Inflammation/Immunology
Target	10 μM (Syk) in human and rat mast cells[1]
References	[1]. Katsuhiro Moriya, et al. ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcɛ receptor I-mediated activation of Syk. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23): 12539–12544. [2]. Yoshitaka Sato, et al. IgG-mediated signal transduction in canine mastocytoma-derived cells. Int Arch Allergy Immunol. 2002 Dec;129(4):305-13.