Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MDBN
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: MNS
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

ShangHai DC Chemicals Co.,Ltd
China
Product Name: MNS
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,4-Methylenedioxy-beta-nitrostyrene
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

1485-00-3

1485-00-3 structure

Name: MDBN
Chemical Name: 3,4-Methylenedioxy-beta-nitrostyrene
CAS Number: 1485-00-3
Molecular Formula: C₉H₇NO₄
Molecular Weight: 193.156
Catalog: Chemical reagent Organic reagent Olefins (cyclic and non-cyclic)
Create Date: 2018-10-12 15:51:39
Modify Date: 2024-01-02 18:32:22
MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1]IC50:29.3 (src), 2.5 uM (syk); [1]In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2]

Name	3,4-Methylenedioxy-beta-nitrostyrene
Synonyms	1,3-Benzodioxole, 5- (2-nitroethenyl)- 3,4-Methylenedioxy-β-nitrostyrene 5-[(E)-2-Nitrovinyl]-1,3-benzodioxole 1,3-Benzodioxole, 5-[(E)-2-nitroethenyl]- T56 BO DO CHJ G1U1NW MFCD00014575 5-(2-Nitrovinyl)benzo[d][1,3]dioxole MNS

Description	MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1]IC50:29.3 (src), 2.5 uM (syk); [1]In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2]
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk Research Areas >> Cancer
References	[1]. Wang WY et al. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosinekinase inhibitor. Mol Pharmacol. 2006 Oct;70(4):1380-9. [2]. Wang WY et al. Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitorswith potent antiplatelet activity. Biochem Pharmacol. 2007 Aug 15;74(4):601-11.

Density	1.4±0.1 g/cm3
Boiling Point	334.9±11.0 °C at 760 mmHg
Melting Point	159-163 °C
Molecular Formula	C₉H₇NO₄
Molecular Weight	193.156
Flash Point	168.8±21.3 °C
Exact Mass	193.037506
PSA	64.28000
LogP	2.27
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.640
Storage condition	Store at +4°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WL5270000

CHEMICAL NAME :: Styrene, 3,4-methylenedioxy-beta-nitro-

CAS REGISTRY NUMBER :: 1485-00-3

BEILSTEIN REFERENCE NO. :: 0192350

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H7-N-O4

MOLECULAR WEIGHT :: 193.17

WISWESSER LINE NOTATION :: T56 BO DO CHJ G1U1NW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,375,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00689

Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S36/37/39-S26-S45
RIDADR	UN 2811 6.1/PG 3
RTECS	WL5270000
HS Code	2932999099

120-57-0

75-52-5

~99%

1485-00-3

Literature: McNulty, James; Steere, Jennifer A.; Wolf, Sonja Tetrahedron Letters, 1998 , vol. 39, # 44 p. 8013 - 8016

2373-80-0

~87%

1485-00-3

Literature: Manna, Srimanta; Jana, Sandipan; Saboo, Tapish; Maji, Arun; Maiti, Debabrata Chemical Communications, 2013 , vol. 49, # 46 p. 5286 - 5288

120-57-0

~80%

1485-00-3

Literature: Abbott Laboratories Patent: US6162927 A1, 2000 ; US 6162927 A

40288-64-0

~71%

1485-00-3

Literature: Hirao, Haruna; Yamauchi, Satoshi; Ishibashi, Fumio Bioscience, Biotechnology and Biochemistry, 2007 , vol. 71, # 3 p. 741 - 745

120-57-0

75-52-5

~31%

1485-00-3

40288-64-0

Literature: Research on Chemical Intermediates, , vol. 39, # 8 p. 3715 - 3725

Precursor 4
120-57-0 75-52-5 2373-80-0 40288-64-0
DownStream 9
21473-47-2 522-97-4 4439-02-5 1484-85-1
173937-91-2 73304-06-0 6882-28-6 79238-83-8
905564-21-8

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	930439-75-1
1018584-77-4	2307738-08-3
2138365-54-3	1375289-11-4