1386439-51-5
1386439-51-5 structure
- Name: SR1555
- Chemical Name: 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone
- CAS Number: 1386439-51-5
- Molecular Formula: C22H22F6N2O2
- Molecular Weight: 460.41300
- Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
- Create Date: 2017-12-21 13:49:38
- Modify Date: 2024-01-29 17:00:38
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SR1555 is a specific retinoic acid receptor-related orphan nuclear receptor γ (RORγ) inverse agonist with an IC50 value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases[1].
| Name | 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone |
|---|---|
| Synonyms | SR1555 |
| Description | SR1555 is a specific retinoic acid receptor-related orphan nuclear receptor γ (RORγ) inverse agonist with an IC50 value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases[1]. |
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| Related Catalog | |
| Target |
RORγ:1 μM (IC50) |
| In Vitro | SR1555 (10 μM; 24 h) inhibits Il17a gene expression by greater than 70%in EL4 cells[1]. SR1555 (10 μM; 24 h) inhibits IL-17 protein expression, inhibits TH17 cell differentiation and function, and does not induce cell death during TH17 cell differentiation[1]. SR1555 (10 μM; 24 h) effectively increases the gene expression of Foxp3 while simultaneously suppressing the gene expression of Rorγt[1]. SR1555 increases the frequency of T regulatory cells as evidenced by the almost 2-fold increase in the expression of Foxp3+ T cells in the splenocyte culture[1]. RT-PCR[1] Cell Line: EL4 cells Concentration: 10 μM Incubation Time: 24 h Result: Inhibited Il17a gene expression by greater than 70%. Cell Differentiation Assay[1] Cell Line: Splenocytes (cultured under TH17 polarizing conditions for 3 days) Concentration: 10 μM Incubation Time: 24 h Result: Inhibited IL-17 protein expression, inhibited TH17 cell differentiation and function, and did not induce cell death during TH17 cell differentiation. RT-PCR[1] Cell Line: Splenocytes (cultured under T regulatory cell polarizing conditions for 3 days) Concentration: 10 μM Incubation Time: 24 h Result: Effectively increased the gene expression of Foxp3 while simultaneously suppressing the gene expression of Rorγt. |
| References |
| Molecular Formula | C22H22F6N2O2 |
|---|---|
| Molecular Weight | 460.41300 |
| Exact Mass | 460.15900 |
| PSA | 43.78000 |
| LogP | 4.20570 |
| Storage condition | 2-8°C |
| Hazard Statements | H413 |
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| RIDADR | NONH for all modes of transport |