Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-DEMETHYLCOLCHICINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

7336-36-9

7336-36-9 structure

Name: 2-demethylcolchicine
Chemical Name: 2-demethylcolchicine
CAS Number: 7336-36-9
Molecular Formula: C₂₁H₂₃NO₆
Molecular Weight: 385.41000
Create Date: 2017-11-12 17:45:06
Modify Date: 2024-01-09 16:35:01

Name	2-demethylcolchicine
Synonyms	O2-Demethylcolchicin 2-O-demethylcolchicine 3-demethylcolchicine

Density	1.31g/cm3
Boiling Point	766.1ºC at 760mmHg
Molecular Formula	C₂₁H₂₃NO₆
Molecular Weight	385.41000
Flash Point	417.1ºC
Exact Mass	385.15300
PSA	94.09000
LogP	2.95950

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0880000

CHEMICAL NAME :: Colchicine, O(sup 2)-demethyl-

CAS REGISTRY NUMBER :: 7336-36-9

LAST UPDATED :: 199409

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H23-N-O6

MOLECULAR WEIGHT :: 385.45

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMV1 NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,453,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16577 ug/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

64-86-8

~46%

7336-36-9

Literature: Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261

64-86-8

~18%

7336-36-9

57866-21-4

78231-83-1

Literature: Kitajima, Mariko; Tanaka, Akiko; Kogure, Noriyuki; Takayama, Hiromitsu Tetrahedron Letters, 2008 , vol. 49, # 2 p. 257 - 260

64-86-8

7336-36-9

78231-83-1

Literature: Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688

186581-53-3

33530-04-0

64-86-8

7336-36-9

Detail

Literature: Chommadov, B. Ch.; Yusupov, M. K.; Aslanov, Kh. A. Chemistry of Natural Compounds, 1991 , vol. 27, # 1 p. 58 - 61 Khimiya Prirodnykh Soedinenii, 1991 , # 1 p. 67 - 71

Precursor 3
64-86-8 186581-53-3 33530-04-0
DownStream 1
78231-83-1

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