7336-36-9

• 常用中文名：2-demethylcolchicine
• 常用英文名：2-demethylcolchicine
• CAS号：7336-36-9
• 分子式：C₂₁H₂₃NO₆
• 分子量：385.41000
• 发布时间：2017-11-12 17:45:06
• 更新时间：2024-01-09 16:35:01

名称

• 英文名: 2-demethylcolchicine
• 英文别名: O2-Demethylcolchicin; 2-O-demethylcolchicine; 3-demethylcolchicine

物化性质

• 密度: 1.31g/cm3
• 沸点: 766.1ºC at 760mmHg
• 分子式: C₂₁H₂₃NO₆
• 分子量: 385.41000
• 闪点: 417.1ºC
• 精确质量: 385.15300
• PSA: 94.09000
• LogP: 2.95950

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0880000 CHEMICAL NAME : Colchicine, O(sup 2)-demethyl- CAS REGISTRY NUMBER : 7336-36-9 LAST UPDATED : 199409 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C21-H23-N-O6 MOLECULAR WEIGHT : 385.45 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JMV1 NO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 75 ug/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 19 mg/kg TOXIC EFFECTS : Behavioral - food intake (animal) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,453,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 16 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 16577 ug/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

合成路线

64-86-8 ~46% 7336-36-9

文献：Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261

64-86-8 ~18% 7336-36-9 57866-21-4 78231-83-1

文献：Kitajima, Mariko; Tanaka, Akiko; Kogure, Noriyuki; Takayama, Hiromitsu Tetrahedron Letters, 2008 , vol. 49, # 2 p. 257 - 260

64-86-8 ~% 7336-36-9 78231-83-1

文献：Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688

186581-53-3 33530-04-0 ~% 64-86-8 7336-36-9 详细

文献：Chommadov, B. Ch.; Yusupov, M. K.; Aslanov, Kh. A. Chemistry of Natural Compounds, 1991 , vol. 27, # 1 p. 58 - 61 Khimiya Prirodnykh Soedinenii, 1991 , # 1 p. 67 - 71

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64-86-8 186581-53-3 33530-04-0
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78231-83-1