78231-83-1

• 常用中文名：1, 2-Didemethylcolchicine
• 常用英文名：1, 2-Didemethylcolchicine
• CAS号：78231-83-1
• 分子式：C₂₀H₂₁NO₆
• 分子量：371.38400
• 发布时间：2017-07-07 15:24:52
• 更新时间：2024-01-10 12:10:06

名称

• 英文名: N-(1,2-dihydroxy-3,10-dimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
• 英文别名: Acetamide,N-(5,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo(a)heptalen-7-yl)-,(S); 1,2-Didemethylcolchicine; Acetamide,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S); 1,2-O-didemethylcolchicine

物化性质

• 密度: 1.38g/cm3
• 沸点: 783.5ºC at 760 mmHg
• 分子式: C₂₀H₂₁NO₆
• 分子量: 371.38400
• 闪点: 427.6ºC
• 精确质量: 371.13700
• PSA: 105.09000
• LogP: 2.65650
• 折射率: 1.642

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AC8585500 CHEMICAL NAME : Acetamide, N-(5,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9- oxobenzo(a)heptalen-7 -yl)-, (S)- CAS REGISTRY NUMBER : 78231-83-1 LAST UPDATED : 198912 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C20-H21-N-O6 MOLECULAR WEIGHT : 371.42 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 167 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983

合成路线

7336-36-9 ~25% 78231-83-1

文献：Muzaffar, Anjum; Chrzanowska, Maria; Brossi, Arnold Heterocycles, 1989 , vol. 28, # 1 p. 365 - 372

64-86-8 ~27% 7336-36-9 57866-21-4 78231-83-1

文献：Kitajima, Mariko; Tanaka, Akiko; Kogure, Noriyuki; Takayama, Hiromitsu Tetrahedron Letters, 2008 , vol. 49, # 2 p. 257 - 260

64-86-8 ~% 7336-36-9 78231-83-1

文献：Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688

64-86-8 ~% 78231-83-1

文献：Muzaffar, Anjum; Chrzanowska, Maria; Brossi, Arnold Heterocycles, 1989 , vol. 28, # 1 p. 365 - 372

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