DC Chemicals Limited
China
Product Name: ent-Ezetimibe
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Purity: 98.0%
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Contact: Tony Cao

1376614-99-1

1376614-99-1 structure

1376614-99-1 structure

Name: ent-Ezetimibe
Chemical Name: ezetimibe
CAS Number: 1376614-99-1
Molecular Formula: C₂₄H₂₁F₂NO₃
Molecular Weight: 409.42500
Catalog: Research Areas Cardiovascular Disease
Create Date: 2019-01-02 07:44:31
Modify Date: 2024-01-04 11:54:17
ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator[1].

Name	ezetimibe
Synonyms	ent-Ezetimibe (3S,4R)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone Ezetimibe Impurity 1

Description	ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator[1].
Related Catalog	Research Areas >> Cardiovascular Disease
References	[1]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [2]. Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. An International Journal for Rapid Communication of Synthetic Organic Chemistry

Molecular Formula	C₂₄H₂₁F₂NO₃
Molecular Weight	409.42500
Exact Mass	409.14900
PSA	60.77000
LogP	4.95330

Hazard Codes	Xi