353495-22-4
353495-22-4 structure
- Name: Phox-I2
- Chemical Name: Phox-I2
- CAS Number: 353495-22-4
- Molecular Formula: C18H15N3O4
- Molecular Weight: 337.33
- Create Date: 2018-01-15 08:01:09
- Modify Date: 2024-07-19 10:42:32
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Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production[1].
| Name | Phox-I2 |
|---|
| Description | Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production[1]. |
|---|---|
| Related Catalog | |
| Target |
Kd: 150 nM (p67phox)[1] |
| In Vitro | Phox-I2 可有效抑制 dHL-60 细胞和原代人中性粒细胞中 NOX2 介导的超氧化物产生，并具有剂量依赖性，且没有可检测到的细胞毒性[1]。 |
| References |
| Molecular Formula | C18H15N3O4 |
|---|---|
| Molecular Weight | 337.33 |
| Exact Mass | 337.10600 |
| PSA | 103.67000 |
| LogP | 5.51390 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H335 |
| Precautionary Statements | P261 |
| RIDADR | NONH for all modes of transport |