DC Chemicals Limited
China
Product Name: VU0420373
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-[5-(2-Fluorophenyl)-1H-pyrazol-3-yl]-phenol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

38376-29-3

38376-29-3 structure

38376-29-3 structure

Name: VU0420373
Chemical Name: 2-(3-(2-fluorophenyl)-1H-pyrazol-5-yl)phenol
CAS Number: 38376-29-3
Molecular Formula: C₁₅H₁₁FN₂O
Molecular Weight: 254.25900
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-03-17 11:46:45
Modify Date: 2024-01-08 15:31:20
VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus[1].

Name	2-(3-(2-fluorophenyl)-1H-pyrazol-5-yl)phenol

Description	VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus[1].
Related Catalog	Research Areas >> Infection Research Areas >> Metabolic Disease Signaling Pathways >> Anti-infection >> Bacterial
Target	EC50: 10.7 μM (HssRS)[1] pEC50: 4.97 (HssRS)[1]
In Vitro	VU0420373 (compound 2e) has an IC50 of >60 μM for Newman aerobic and Newman anaerobic, respectively[1]. VU0420373 (40 μM; 2, 4, 6, 8 hours) is able to preadapt S. aureus to a toxic concentration of heme (20 μM)[1].
References	[1]. Brendan F Dutter, et al. Decoupling Activation of Heme Biosynthesis From Anaerobic Toxicity in a Molecule Active in Staphylococcus Aureus. ACS Chem Biol. 2016 May 20;11(5):1354-61.

Molecular Formula	C₁₅H₁₁FN₂O
Molecular Weight	254.25900
Exact Mass	254.08600
PSA	48.91000
LogP	3.58840

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport