28360-49-8

28360-49-8 structure

Name: Mahanine
Chemical Name: mahanine
CAS Number: 28360-49-8
Molecular Formula: C₂₃H₂₅NO₂
Molecular Weight: 347.45000
Catalog: Research Areas Cancer
Create Date: 2018-03-17 17:32:24
Modify Date: 2024-01-03 19:22:33
Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection treatment research[1].

Name	mahanine

Description	Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection treatment research[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Research Areas >> Inflammation/Immunology
In Vitro	Mahanine (0-50 µM; 24 or 48 hours) induces a dose-dependent decrease in cell viability of AG83 promastigotes after 24 hr and 48 hr; the IC50 values were 16.7±1.7 µM and 11.5±0.8 µM respectively. In a drug resistant GE1 strain, Mahanine treatment exhibits dose-dependent cell death in 24 and 48 hr treatment with IC50 values 40.3±2.2 µM and 29.1±1.3 µM respectively[1]. Mahanine (5.0 and 10 µM; 24 hours) exhibits increased accumulation of cells at G2/M phase being 39.0±1.90% and 41.0±2.10% respectively compared to untreated promastigotes (35.3 ± 2.60%) in AG83 promastigote [1]. Mahanine (25 µM; 24 hours) exhibitssignificantly increased intracellular ROS level within 20 min (MFI being 889 ± 26) which reached to 1288 ± 56 after one hour compared to the basal level (604 ± 34) in untreated promastigote. H2DCFDA positivity was measured by FACS[1].
In Vivo	Mahanine (oral gavage; 20 mg/kg/40 mg/kg; b.w/day; 5 days) results in 89.1±4.1% reductions in parasite burden at 20 mg/kg, and leads to 96.2±0.3% reductions in parasite burden at 40 mg/kg in a well-established acute model to control Leishmania infection[1]. Animal Model: Balb/c mice with virulent AG83 promastigotes[1] Dosage: 20 mg/kg-40 mg/kg Administration: oral gavage; 20 mg/kg/40 mg/kg; b.w/day; 5 days Result: Had the potential to clear parasite burden in vivo. Exhibited almost complete reduction of parasite burden, upregulation of NO/iNOS/ROS/IL-12 and T cell proliferation in vivo.
References	[1]. Kaushik Bhattacharya, et al. Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways. Biochem Pharmacol. 2010 Feb 1;79(3):361-72. [2]. Saptarshi Roy, et al. Mahanine exerts in vitro and in vivo antileishmanial activity by modulation of redox homeostasis. Sci Rep

Molecular Formula	C₂₃H₂₅NO₂
Molecular Weight	347.45000
Exact Mass	347.18900
PSA	45.25000
LogP	6.24580

Hazard Codes	Xi