- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Furanodienone
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- BioBioPha
- China
- Product Name: Furanodienone
- Price: ￥Inquiry/5mg
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Furanodienone
- Price: ￥1378.0/20mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Furanodienone
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
24268-41-5
24268-41-5 structure
- Name: Furanodienone
- Chemical Name: furanodienone
- CAS Number: 24268-41-5
- Molecular Formula: C15H18O2
- Molecular Weight: 230.302
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-05-04 08:00:00
- Modify Date: 2024-01-02 17:04:53
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Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1].
| Name | furanodienone |
|---|---|
| Synonyms |
Furanodienon
Cyclodeca[b]furan-4(7H)-one, 8,11-dihydro-3,6,10-trimethyl-, (5Z)- furanodien-6-one (5Z)-3,6,10-Trimethyl-8,11-dihydrocyclodeca[b]furan-4(7H)-one furanodiene-6-one (1(10)E,4E)-8,12-epoxygermacra-1(10),4,7,11-tetraen-6-one (5E,9E)-3,6,10-Trimethyl-8,11-dihydro-7H-cyclodeca[b]furan-4-one |
| Description | Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Furanodienone (0-573.8 μM; 24 hours) exhibits IC50 values : 56.4 μM (RKO), 73.7 μM (sw480), 251.1 μM (HT-29), 412.5 μM (sw620) and 573.8 μM (LoVo) at 24 hours, while that in 48 h are 51.8 μM (RKO), 44.18 μM (sw480), 168.9 μM (HT-29), 314.2 μM (sw620) and 502.1 μM (LoVo), respectively[1]. Furanodienone (0-150 μM; 24 hours) induces apoptosis and shows increase in caspase-9 and -3 activity has been observed in both cells, whereas a relative minor effect on that of caspase-8 in RKO and HT-29 cells[1]. Furanodienone (0-150 μM; 24 hours) increases the apoptotic rates from 2.34±0.45% to 19.45±2.37% and 27.34±0.79%, in RKO cells at 75 and 150 μM. whereas 12.4±1.08 and 20.64±3.02% apoptosis at the concentration of 75 and 150 μM are observed in HT-29 cells compared with 2.89±0.26%[1]. Western Blot Analysis[1] Cell Line: RKO and HT-29 cells Concentration: 0 μM; 50 μM; 100 μM; 150 μM Incubation Time: 24 hours Result: Increased caspase-9 and -3. Apoptosis Analysis[1] Cell Line: RKO and HT-29 cells Concentration: 0 μM; 75 μM; 150 μM Incubation Time: 24 hours Result: Induced apoptosis of colorectal cells (RKO and HT-29). |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 363.8±42.0 °C at 760 mmHg |
| Molecular Formula | C15H18O2 |
| Molecular Weight | 230.302 |
| Flash Point | 172.0±20.6 °C |
| Exact Mass | 230.130676 |
| PSA | 30.21000 |
| LogP | 4.76 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.510 |
| Storage condition | 2-8℃ |