220509-74-0

220509-74-0 structure

Name: MMPSI
Chemical Name: (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
CAS Number: 220509-74-0
Molecular Formula: C₁₄H₁₆N₂O₅S
Molecular Weight: 324.35
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-04-21 06:54:14
Modify Date: 2024-01-09 19:48:36
MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection[1].

Name	(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Synonyms	(S)-5-[1-(2-(methoxymethyl)pyrrolidinyl)sulfonyl]isatin (S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione 5-((S)-2-Methoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione (S)-5-((2-(methoxymethyl)pyrrolidin-1-yl)sulfonyl)indoline-2,3-dione 5-(S)-(2-methoxymethyl)pyrrolidinylsulfonyl isatin (S)-(+)-5-[2-methoxymethylpyrrolidin-1-ylsulfonyl]isatin (S)-5-[(2-methoxymethylpyrrolidin-1-yl)sulfonyl]isatin

Description	MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cardiovascular Disease Signaling Pathways >> Apoptosis >> Caspase
Target	human Caspase-3:1.7 μM (IC50)
References	[1]. Chapman JG, et al, Tracey WR. A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury. Eur J Pharmacol. 2002;456(1-3):59-68.