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  • DC Chemicals Limited
  • China
  • Product Name: Ki16198
  • Price: $600.0/100mg $1100.0/250mg $2300.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

355025-13-7

355025-13-7 structure
355025-13-7 structure
  • Name: Ki16198
  • Chemical Name: Methyl 3-({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-met hyl-1,2-oxazol-5-yl]benzyl}sulfanyl)propanoate
  • CAS Number: 355025-13-7
  • Molecular Formula: C24H25ClN2O5S
  • Molecular Weight: 488.984
  • Catalog: Biochemical Inhibitor G protein coupled receptor(GPCR & G Protein) LPA Receptor Antagonist
  • Create Date: 2016-12-30 17:45:51
  • Modify Date: 2024-01-14 09:13:22
  • Ki16198 is a potent and orally active LPA receptor antagonist, the methyl ester of Ki16425 (HY-13285). Ki16198 inhibits LPA1 and LPA3-induced inositol phosphate production with Ki values of 0.34 μM and 0.93 μM, respectively. Ki16198 is effective for pancreatic cancer tumorigenesis and metastasis in vivo[1].

Name Methyl 3-({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-met hyl-1,2-oxazol-5-yl]benzyl}sulfanyl)propanoate
Synonyms Methyl 3-({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]benzyl}sulfanyl)propanoate
Propanoic acid, 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]-, methyl ester
Ki16198
Description Ki16198 is a potent and orally active LPA receptor antagonist, the methyl ester of Ki16425 (HY-13285). Ki16198 inhibits LPA1 and LPA3-induced inositol phosphate production with Ki values of 0.34 μM and 0.93 μM, respectively. Ki16198 is effective for pancreatic cancer tumorigenesis and metastasis in vivo[1].
Related Catalog
Target

Ki: 0.34 μM (LPA1 receptor) Ki: 0.93 μM (LPA1 receptor)[1]

In Vitro Ki16198 (0-10 μM; 48 hours) is effective to inhibit migration and invasion responses to LPA with a potency similar to that of Ki16425. The inhibitory effects Ki16198 on the invasion response to LPA, but not to EGF in several pancreatic cancer cell lines, including Panc-1,CFPAC-1, and BxPC-3 cells[1]. Ki16198 (10 μM; 48 hours) signifivcantly decreases expression of proMMP-9 protein and mRNA expression in YAPC-PD cells[1].
In Vivo Ki16198 (oral administaion; 1 mg in 500 ul; 28 days) significantly decreases the degree of metastasis activity in Ki16198-treated mice. Similiar to liver, metastasis to lung and brain in mice is also observed[1]. Animal Model: Male BALB/c nude mice (6 weeks old)[1] Dosage: 1 mg in 500 ul Administration: Oral administaion; 28 days Result: Inhibited lung and liver metastasis in vivo.
References

[1]. Mayumi Komachi, et al. Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo. Cancer Sci. 2012 Jun;103(6):1099-104.

Density 1.3±0.1 g/cm3
Boiling Point 594.2±50.0 °C at 760 mmHg
Molecular Formula C24H25ClN2O5S
Molecular Weight 488.984
Flash Point 313.2±30.1 °C
Exact Mass 488.117279
PSA 119.45000
LogP 5.19
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.604
Storage condition -20℃