138039-33-5

138039-33-5 structure

Name: (-)-3-<(1E)-1,3-dimethylpent-1-enyl>-10-hydroxy-7-methoxy-1H-naphtho<2,3-c>pyran-8,9(8H)-dione
Chemical Name: (-)-3-<(1E)-1,3-dimethylpent-1-enyl>-10-hydroxy-7-methoxy-1H-naphtho<2,3-c>pyran-8,9(8H)-dione
CAS Number: 138039-33-5
Molecular Formula: C₂₁H₂₂O₅
Molecular Weight: 354.39600
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2018-02-01 17:22:00
Modify Date: 2024-03-03 15:15:29
Leptosphaerodione, isolated from Remotididymella sp. Fungus, is a potent ubiquitin-proteasome system (UPS) inhibitor. Leptosphaerodione exhibits cytotoxicity in HeLa cells with IC50 value of 3.2 μM. Anti-tumor agent[1].

Name	(-)-3-<(1E)-1,3-dimethylpent-1-enyl>-10-hydroxy-7-methoxy-1H-naphtho<2,3-c>pyran-8,9(8H)-dione
Synonyms	(-)-3-((1E)-1,3-dimethylpent-1-enyl)-10-hydroxy-7-methoxy-1H-naphtho[2,3-c]pyran-8,9(8H)-dione leptosphaerodione 3-((E)-1,3-Dimethyl-pent-1-enyl)-10-hydroxy-7-methoxy-1H-benzo[g]isochromene-8,9-dione

Description	Leptosphaerodione, isolated from Remotididymella sp. Fungus, is a potent ubiquitin-proteasome system (UPS) inhibitor. Leptosphaerodione exhibits cytotoxicity in HeLa cells with IC50 value of 3.2 μM. Anti-tumor agent[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
References	[1]. Soichiro Nishimura, et al. Cell-based screening of extracts of natural sources to search for inhibitors of the ubiquitin-proteasome system and identification of proteasome inhibitors from the fungus Remotididymella sp. Bioorg Med Chem Lett. 2022 Ma