88150-59-8

88150-59-8 structure

Name	uk-51656
Synonyms	2-(2-{[4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}ethylamino)acetamide 2-[2-(Carbamoylmethyl-amino)-ethoxymethyl]-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 2-<<2-<N-<(aminocarbonyl)methyl>amino>ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine UK51656

Description	UK51656 is a calcium antagonist with IC50 of 4 nM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
Target	IC50: 4 nM (calcium)[1]
In Vivo	UK51656 has an elimination half-life of 4.7 h, which is consistent with its duration of action in the anesthetized dog. The effect of UK51656 on coronary vascular resistance, has markedly long durations, being over 5 h[1].
References	[1]. Alker D, et al. Long-acting dihydropyridine calcium antagonists. 4. Synthesis and structure-activity relationships for a series of basic and nonbasic derivatives of 2-[(2-aminoethoxy)methyl]-1,4-dihydropyridine calcium antagonists. J Med Chem. 1990 Feb;33(2):585-91.