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149709-63-7

149709-63-7 structure
149709-63-7 structure

Name 4-{[(2S,4S)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid
Synonyms [1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, α-ethyl ester, (αS,γS)-
4-{[(2S,4S)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid
4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid
LCZ696 impurity 17
Description 2S,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.
Related Catalog
References

[1]. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.

Density 1.2±0.1 g/cm3
Boiling Point 656.9±55.0 °C at 760 mmHg
Molecular Formula C24H29NO5
Molecular Weight 411.491
Flash Point 351.1±31.5 °C
Exact Mass 411.204559
LogP 3.96
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.549
Storage condition 2-8℃