216974-75-3
216974-75-3 structure
- Name: Bevacizumab
- Chemical Name: Lithium 4-{[2-(diethylamino)ethyl]carbamoyl}-2-iodobenzoate
- CAS Number: 216974-75-3
- Molecular Formula: C14H18ILiN2O3
- Molecular Weight: 396.150
- Catalog: API Hormone and endocrine-regulating drugs Adrenal corticosteroids
- Create Date: 2018-06-19 23:06:44
- Modify Date: 2024-01-02 11:13:03
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Bevacizumab, as a humanized vascular endothelial growth factor (VEGF) antibody, is a highly effective monoclonal antibody. Bevacizumab can be used for the research of cancer[1][2].
| Name | Lithium 4-{[2-(diethylamino)ethyl]carbamoyl}-2-iodobenzoate |
|---|---|
| Synonyms |
Lithium 4-{[2-(diethylamino)ethyl]carbamoyl}-2-iodobenzoate
Benzoic acid, 4-[[[2-(diethylamino)ethyl]amino]carbonyl]-2-iodo-, lithium salt (1:1) |
| Description | Bevacizumab, as a humanized vascular endothelial growth factor (VEGF) antibody, is a highly effective monoclonal antibody. Bevacizumab can be used for the research of cancer[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Bevacizumab-loaded hydrogel results in significant tumor reduction. Bevacizumab is taken up by other organs, including the heart, lung, and spleen. Bevacizumab accumulates higher within tumors via Bevacizumab-loaded hydrogel administration from 14 days onward as compared to the solution formulation. Bevacizumab (I.v.) solution, a typical drug clearance profile is observed where the antibody is cleared from the circulatory system with a half-life of ~4~5 days. The Bevacizumab-loaded hydrogel and the weekly administration of Bevacizumab solution inhibits tumor growth/metastasis in the peritoneal cavity, while one-time i.v. injection of Bevacizumab solution does not provide any therapeutic effect, leading to extensive tumor metastasis[2]. |
| References |
| Molecular Formula | C14H18ILiN2O3 |
|---|---|
| Molecular Weight | 396.150 |
| Exact Mass | 396.052216 |