1356016-86-8

1356016-86-8 structure

Name: (4R)-4-Hydroxy-L-(2,5,5-2H3)proline
Chemical Name: (4R)-4-Hydroxy-L-(2,5,5-2H3)proline
CAS Number: 1356016-86-8
Molecular Formula: C₅H₆D₃NO₃
Molecular Weight: 134.148
Catalog: Research Areas Others
Create Date: 2018-04-02 00:40:44
Modify Date: 2024-01-02 18:34:41
L-Hydroxyproline-d3 is the deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.

Name	(4R)-4-Hydroxy-L-(2,5,5-2H3)proline
Synonyms	(4R)-4-Hydroxy-L-(2,5,5-H)proline L-Proline-2,5,5-d, 4-hydroxy-, (4R)-

Description	L-Hydroxyproline-d3 is the deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
Related Catalog	Research Areas >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Yi Y, et al. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli. BMC Biotechnol. 2014 May 19;14:44.