727699-84-5

727699-84-5 structure

Name: N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide
Chemical Name: N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide
CAS Number: 727699-84-5
Molecular Formula: C₂₆H₂₁FN₂O₄S
Molecular Weight: 476.522
Catalog: Signaling Pathways Immunology/Inflammation STING
Create Date: 2018-06-05 13:04:02
Modify Date: 2024-01-16 12:21:12
SN-001 is a STING inhibitor with an IC50 of 3.82 μM[1].

Name	N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide
Synonyms	MLS000417014 N-(3-(4-fluorophenylsulfonamido)-4-methoxyphenyl)-[1,1'-biphenyl]-4-carboxamide

Description	SN-001 is a STING inhibitor with an IC50 of 3.82 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> STING
Target	IC50: 3.82 μM (STING)[1]
In Vitro	SN-001 targets the cyclic dinucleotide binding pocket of human STING[1]. SN-001 (5-20 μM; 6 h) significantly impairs the induction of Ifnb mRNA, in a dose-dependent manner in L929 cells[1]. SN-001 (10 μM; 3 h) inhibits cytosolic DNA-triggered STING signaling[1]. Western Blot Analysis[1] Cell Line: L929 cells Concentration: 10 μM Incubation Time: 3 h Result: Decreased cytosolic DNA-induced phosphorylation of STING, TBK1, IRF3, IκBα, and p65, as well as nuclear translocation of IRF3 and p65.