Shanghai Nianxing Industrial Co., Ltd
China
Product Name: RO5028442
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

ShangHai DC Chemicals Co.,Ltd
China
Product Name: RO 5028442
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: RO 5028442
Price: $750.0/100mg $1350.0/250mg $2700.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: RG7314
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

920022-47-5

920022-47-5 structure

920022-47-5 structure

Name: RO5028442
Chemical Name: RG7314
CAS Number: 920022-47-5
Molecular Formula: C₂₅H₂₈ClN₃O₂
Molecular Weight: 437.962
Catalog: Signaling Pathways GPCR/G Protein Vasopressin Receptor
Create Date: 2018-05-20 08:00:00
Modify Date: 2024-01-16 07:26:42
RO5028442 is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).

Name	RG7314
Synonyms	Methanone, [6-chloro-1-[2-(dimethylamino)ethyl]-1H-indol-3-yl]spiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl- RO-5028442 UNII:LZ0EU1YHCK RG7314 {6-Chloro-1-[2-(dimethylamino)ethyl]-1H-indol-3-yl}(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)methanone RO 5028442 RO5028442

Description	RO5028442 is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor Research Areas >> Neurological Disease
Target	Ki: 1 nM (hV1a receptor), 39 nM (mV1a receptor)[1]
In Vitro	RO5028442 (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RO5028442 shows high solubility. RO5028442 is found to be highly selective against a panel of 89 targets. Finally, RO5028442 is identified as a suitable compound for clinical studies[1].
Cell Assay	CHO cells are stably transfected with expression plasmids encoding human V1a and grown in F-12 K, containing 10% fetal bovine serum, 1% penicillin-streptomycin, 1% glutamate, and 200 μg/mL geneticin at 37 °C in a 10% CO2 incubator at 95% humidity. Cells are plated for 24 h at 50,000 cells/well in clear bottomed 96 well plates and are dye loaded for 60 min with 2 μM Fluo-4-AM in assay buffer. After cell washing, the plate is loaded on a ﬂuorometricimaging plate reader, compound dilution series added to the cells, and agonist activity measured[1].
References	[1]. Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.

Density	1.3±0.1 g/cm3
Boiling Point	621.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₅H₂₈ClN₃O₂
Molecular Weight	437.962
Flash Point	329.6±31.5 °C
Exact Mass	437.187012
LogP	3.68
Appearance	white solid
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.646
Storage condition	-20℃