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1417997-93-3

1417997-93-3 structure
1417997-93-3 structure
  • Name: HDAC8-IN-1
  • Chemical Name: HDAC8-IN-1
  • CAS Number: 1417997-93-3
  • Molecular Formula: C22H19NO3
  • Molecular Weight: 345.39
  • Catalog: Research Areas Cancer
  • Create Date: 2018-05-21 08:00:00
  • Modify Date: 2024-02-07 15:48:58
  • HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.

Name HDAC8-IN-1
Synonyms MFCD31619280
Description HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.
Related Catalog
Target

HDAC8:27.2 nM (IC50)

In Vitro HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells[1].
References

[1]. Huang WJ, et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem. 2012 Oct;7(10):1815-24.

Molecular Formula C22H19NO3
Molecular Weight 345.39
Storage condition 2-8℃