1532533-69-9
1532533-69-9 structure
- Name: TGR-1202 R-enantiomer
- Chemical Name: TGR-1202 R-enantiomer
- CAS Number: 1532533-69-9
- Molecular Formula: C31H24F3N5O3
- Molecular Weight: 571.549
- Catalog: Research Areas Cancer
- Create Date: 2018-04-23 09:48:00
- Modify Date: 2024-01-08 18:12:24
-
Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202.
| Name | TGR-1202 R-enantiomer |
|---|---|
| Synonyms |
2-{(1R)-1-[4-Amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2-[(1R)-1-[4-amino-3-[3-fluoro-4-(1-methylethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)- |
| Description | Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202. |
|---|---|
| Related Catalog | |
| Target |
PI3Kδ |
| In Vitro | Umbralisib R-enantiomer (TGR-1202 R-enantiomer) (Formula A) exhibits a 50% inhibitory concentration (IC50) with respect to the δ type PI3-kinase that is at least 20-fold lower than the inhibitor's IC50 with respect to the rest of the other PI3K isoforms (i.e., a, β, and γ)[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 737.4±60.0 °C at 760 mmHg |
| Molecular Formula | C31H24F3N5O3 |
| Molecular Weight | 571.549 |
| Flash Point | 399.8±32.9 °C |
| Exact Mass | 571.183105 |
| LogP | 6.66 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.666 |
| Storage condition | 2-8℃ |