Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PI3Kα/mTOR-IN-1
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Purity: 99.3%
Stocking Period: 10 Day
Contact: Yang

1013098-90-2

1013098-90-2 structure

1013098-90-2 structure

Name: PI3Kα/mTOR-IN-1
Chemical Name: PI3Kα/mTOR-IN-1
CAS Number: 1013098-90-2
Molecular Formula: C₁₆H₁₈N₆O
Molecular Weight: 310.35
Catalog: Research Areas Cancer
Create Date: 2018-05-04 05:38:56
Modify Date: 2024-01-14 11:58:56
PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively.

Name	PI3Kα/mTOR-IN-1

Description	PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively.
Related Catalog	Research Areas >> Cancer
Target	PI3Kα:7 nM (IC50, Cell Assay) PI3Kα:12.5 nM (Ki) mTOR:10.6 nM (Ki)
In Vitro	PI3Kα/mTOR-IN-1 exhibits potent activity against PI3Kα and mTOR, high LipE, good kinase selectivity and robust ADMET properties[1].
In Vivo	PI3Kα/mTOR-IN-1 exhibits low HLM ER, but it is highly cleared in rat liver microsome (RLM) with ER of 0.88. PI3Kα/mTOR-IN-1 exhibits moderate clearance, moderate Vdss, T1/2 of 0.9 h, and good oral bioavailability[1].
References	[1]. Le PT, et al. Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5098-103.

Molecular Formula	C₁₆H₁₈N₆O
Molecular Weight	310.35