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  • DC Chemicals Limited
  • China
  • Product Name: XEN723
  • Price: ¥650.0/100mg ¥1300.0/250mg ¥2600.0/1g
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Tony Cao

1072803-08-7

1072803-08-7 structure
1072803-08-7 structure
  • Name: XEN723
  • Chemical Name: XEN723
  • CAS Number: 1072803-08-7
  • Molecular Formula: C21H20FN5O2S
  • Molecular Weight: 425.48
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Stearoyl-CoA Desaturase (SCD)
  • Create Date: 2018-03-25 11:53:44
  • Modify Date: 2024-02-04 18:37:37
  • XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.

Name XEN723
Description XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.
Related Catalog
Target

IC50: 45 nM (SCD1 in Mouse), 524 nM (SCD1 in HepG2 cell)[1]

In Vitro XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively. XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit[1].
References

[1]. Sun S, et al. Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorg Med Chem Lett. 2014 Jan 15;24(2):520-5.

Molecular Formula C21H20FN5O2S
Molecular Weight 425.48
Storage condition 2-8℃