1034190-08-3

1034190-08-3 structure

Name: ALZ-801
Chemical Name: GHG2B47067
CAS Number: 1034190-08-3
Molecular Formula: C₈H₁₈N₂O₄S
Molecular Weight: 238.302
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-18 22:38:24
Modify Date: 2024-01-11 21:19:40
ALZ-801 is an orally available, small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound[1]. ALZ-801 is an advanced and markedly improved clinical candidate for the treatment of Alzheimer’s disease[2].

Name	GHG2B47067
Synonyms	GHG2B47067

Description	ALZ-801 is an orally available, small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound[1]. ALZ-801 is an advanced and markedly improved clinical candidate for the treatment of Alzheimer’s disease[2].
Related Catalog	Research Areas >> Neurological Disease
Target	β-amyloid[1]
References	[1]. John A. Hey, et al. Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain. CNS Drugs. 2018; 32(9): 849–861. [2]. Hey JA, et al. Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease. Clin Pharmacokinet. 2018 Mar;57(3):315-333.

Molecular Formula	C₈H₁₈N₂O₄S
Molecular Weight	238.302