1275595-86-2

1275595-86-2 structure

Name: Selatinib
Chemical Name: SELATINIB
CAS Number: 1275595-86-2
Molecular Formula: C₂₉H₂₆ClFN₄O₃S
Molecular Weight: 565.06
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2018-07-21 10:22:20
Modify Date: 2024-01-09 16:26:25
Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects[1].

Name	SELATINIB
Synonyms	4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfinyl)ethyl]amino]methyl]-2-furanyl]- 6TLR8U8O3C N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfinyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine SELATINIB UNII:6TLR8U8O3C

Description	Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:13 nM (IC50) ErbB2:22.5 nM (IC50)
References	[1]. Meng-Na Wang, et al. First-in-human, phase I single-ascending-dose study of the safety, pharmacokinetics, and relative bioavailability of selatinib, a dual EGFR-ErbB2 inhibitor in healthy subjects. Invest New Drugs. 2020 Dec;38(6):1826-1835.