1448345-60-5

1448345-60-5 structure

Name: Albendazole sulfone-D3
Chemical Name: (2H3)Methyl [5-(propylsulfonyl)-1H-benzimidazol-2-yl]carbamate
CAS Number: 1448345-60-5
Molecular Formula: C₁₂H₁₂D₃N₃O₄S
Molecular Weight: 300.349
Catalog: analytical chemistry Standard Forensic and veterinary standards
Create Date: 2018-06-18 04:52:36
Modify Date: 2024-01-07 07:02:01
Albendazole sulfone-d3 is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.

Name	(2H3)Methyl [5-(propylsulfonyl)-1H-benzimidazol-2-yl]carbamate
Synonyms	Carbamic acid, N-[5-(propylsulfonyl)-1H-benzimidazol-2-yl]-, methyl-d3 ester (2H3)Methyl [5-(propylsulfonyl)-1H-benzimidazol-2-yl]carbamate

Description	Albendazole sulfone-d3 is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
Related Catalog	Research Areas >> Infection
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Ingold K, et, al. Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. Antimicrob Agents Chemother. 1999 May;43(5):1052-61. [3]. Adas G, et, al. Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study). World J Gastroenterol. 2009 Jan 7;15(1):112-6.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H317
Precautionary Statements	P280-P301 + P312 + P330
Hazard Codes	Xn
Risk Phrases	22-43
Safety Phrases	36/37
RIDADR	NONH for all modes of transport