159445-64-4

159445-64-4 structure
159445-64-4 structure
  • Name: Odulimomab
  • Chemical Name: Odulimomab
  • CAS Number: 159445-64-4
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Signaling Pathways Cytoskeleton Integrin
  • Create Date: 2018-12-05 08:07:54
  • Modify Date: 2024-02-01 16:32:49
  • Odulimomab (anti-LFA1) is an anti-LFA-1 monoclonal antibody. Odulimomab inhibits proliferation of T lymphocyte and shows protective effects against ischemia and reperfusion injury. Odulimomab can be used for the research of transplant rejection and immunological disease[1][2].

Name Odulimomab
Description Odulimomab (anti-LFA1) is an anti-LFA-1 monoclonal antibody. Odulimomab inhibits proliferation of T lymphocyte and shows protective effects against ischemia and reperfusion injury. Odulimomab can be used for the research of transplant rejection and immunological disease[1][2].
Related Catalog
In Vitro Odulimomab 在体外抑制 T 淋巴细胞增殖,以及 T 和自然杀伤细胞 (NK) 的细胞毒性和抗体产生[2]。
In Vivo Odulimomab (1.5 和 0.75 mg/kg;腹腔注射,第 1 次治疗 1.5 mg/kg,然后每天注射 0.75 mg/kg) 对缺血和再灌注损伤有保护作用,对移植后肾功能有所修复[1]。 Animal Model: Cynomolgus Monkeys with renal damage ischemia and kidney autotransplantation[1] Dosage: 1.5 and 0.75 mg/kg Administration: Intraperitoneal injection; 1.5 mg/kg for the first dose and after pedicle clamping followed by daily injection of 0.75 mg/kg until sacrifice Result: Decreased the creatinine level after ischemia and autotransplantation for 3 days and increased the potassium fraction reabsorption.
References

[1]. Martin X, et al. Protective effect of an anti-LFA 1 monoclonal antibody (odulimomab) on renal damage due to ischemia and kidney autotransplantation. Transplant Proc. 2000 Mar;32(2):481.  

[2]. M. Hourmant & J. P. Soulillou. Interest in an anti-LFA-1 monoclonal antibody in the prevention of reperfusion injury in kidney transplantation. Organ Allocation pp 215–223.

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