375348-49-5

375348-49-5 structure

375348-49-5 structure

Name: Bertilimumab
Chemical Name: Bertilimumab
CAS Number: 375348-49-5
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways GPCR/G Protein CCR
Create Date: 2018-12-02 22:44:08
Modify Date: 2024-06-11 19:34:56
Bertilimumab (CAT 213; iCo-008) is a human monoclonal antibody targeting eotaxin-1 (CCL11). Bertilimumab has the potential for allergic disorders research[1].

Name	Bertilimumab

Description	Bertilimumab (CAT 213; iCo-008) is a human monoclonal antibody targeting eotaxin-1 (CCL11). Bertilimumab has the potential for allergic disorders research[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Signaling Pathways >> Immunology/Inflammation >> CCR Research Areas >> Inflammation/Immunology
In Vitro	Bertilimumab (CAT 213) 中和 eotaxin-1 导致细胞内钙信号传导增加（IC50 值为 2.86 nM）、表达 CCR3 的 L1.2 细胞迁移（具有 IC50 值为 0.48 nM)，在体外抑制 eotaxin-1 诱发的人嗜酸性粒细胞形状变化（IC50 为 0.71 nM）[1 ]。
In Vivo	Bertilimumab (CAT 213) (0.01-10 mg/kg) 静脉内给药 i.po 前 30 分钟注射人 eotaxin1 (1 μg) 在 IL-5 处理的卵白蛋白致敏小鼠中引起显着的剂量依赖性嗜酸性粒细胞募集抑制。Bertilimumab 还显着抑制中性粒细胞和单核细胞流入气囊，从而导致总细胞流入的剂量相关抑制[1]。 Animal Model: Female BALB/c mice (17-21 g) injected human eotaxin1[1]. Dosage: 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 10 mg/kg Administration: i.v; once Result: Caused a significant dose-dependent inhibition of eosinophil recruitment in IL-5-treated, ovalbumin-sensitized mice.
References	[1]. Sarah Main, et al. A potent human anti-eotaxin1 antibody, CAT-213: isolation by phage display and in vitro and in vivo efficacy. J Pharmacol Exp Ther. 2006 Dec;319(3):1395-404.

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