154675-18-0

154675-18-0 structure

Name: HBDDE
Chemical Name: 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether
CAS Number: 154675-18-0
Molecular Formula: C₁₆H₁₈O₈
Molecular Weight: 338.31
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-07-04 19:21:44
Modify Date: 2024-01-10 22:02:27
HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2].

Name	2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether

Description	HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Neurological Disease Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKCα:43 μM (IC50) PKCγ:50 μM (IC50)
In Vitro	HBDDE (50 μM; 5 hours) treatment reduces cell viability significantly by ~70%. HBDDE exhibits a marked increase in caspase-3 activity[1]. Cell Viability Assay[1] Cell Line: Cerebellar granule cells Concentration: 50 μM Incubation Time: 5 hours Result: Reduced cell viability significantly by ~70%.
References	[1]. A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60(6):809-15. [2]. Y Kashiwada, et al. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37(1):195-200.