1802086-22-1

1802086-22-1 structure

Name: (Glu20)-Amyloid β-Protein (1-42)
Chemical Name: (Glu20)-Amyloid β-Protein (1-42)
CAS Number: 1802086-22-1
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Neurological Disease
Create Date: 2018-07-11 06:15:45
Modify Date: 2024-01-03 19:03:12
(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease[1][2].

Name	(Glu20)-Amyloid β-Protein (1-42)

Description	(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease[1][2].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Poduslo JF, et al. Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier. Neurobiol Dis. 1999 Jun;6(3):190-9. [2]. Williams TL, et al. The effect of Alzheimer's Aβ aggregation state on the permeation of biomimetic lipid vesicles. Langmuir. 2010 Nov 16;26(22):17260-8.

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