2220184-50-7
2220184-50-7 structure
- Name: CDK12-IN-3
- Chemical Name: CMPD 7
- CAS Number: 2220184-50-7
- Molecular Formula: C23H28F2N8O
- Molecular Weight: 470.52
- Catalog: Research Areas Cancer
- Create Date: 2018-08-16 19:23:28
- Modify Date: 2024-02-18 17:26:37
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CMPD 7 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.
| Name | CMPD 7 |
|---|
| Description | CMPD 7 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay. |
|---|---|
| Related Catalog | |
| Target |
IC50: 491 nM (CDK12)[1] |
| In Vitro | CMPD 7 is a highly selective CDK12 inhibitor profiled across a panel of 352 kinases at 0.1 µM. CMPD 7 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells[1]. |
| References |
| Molecular Formula | C23H28F2N8O |
|---|---|
| Molecular Weight | 470.52 |