1799506-06-1
1799506-06-1 structure
- Name: VH032-PEG5-C6-Cl (HaloPROTAC 2)
- Chemical Name: HaloPROTAC 2
- CAS Number: 1799506-06-1
- Molecular Formula: C38H59ClN4O9S
- Molecular Weight: 783.41
- Catalog: Signaling Pathways PROTAC PROTAC
- Create Date: 2018-09-30 11:53:05
- Modify Date: 2024-01-02 19:19:10
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HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins.
| Name | HaloPROTAC 2 |
|---|
| Description | HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins. |
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| Related Catalog | |
| In Vitro | HaloPROTAC 1 and HaloPROTAC2, containing different linker lengths, are synthesized. Their ability to degrade GFP-HaloTag7, (stably expressed in HEK 293 cells) is tested tby flow cytometry, measuring changes in mean fluorescence intensity. While 24 hour treatment with HaloPROTAC 1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM[1]. |
| References |
| Molecular Formula | C38H59ClN4O9S |
|---|---|
| Molecular Weight | 783.41 |