2207569-08-0
2207569-08-0 structure
- Name: QCA570
- Chemical Name: QCA570
- CAS Number: 2207569-08-0
- Molecular Formula: C39H33N7O4S
- Molecular Weight: 695.798
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2018-11-18 21:40:28
- Modify Date: 2024-01-16 22:56:16
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QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein.
| Name | QCA570 |
|---|
| Description | QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein. |
|---|---|
| Related Catalog | |
| Target |
BRD4 BD1:10 nM (IC50) |
| In Vitro | QCA570 is an extremely potent and highly efficacious BET degrader, capable of degrading BET proteins at low picomolar (pM) concentrations in leukemia cells. QCA570 inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively. QCA570 is the most potent and efficacious BET degrader reported to date[1]. |
| Animal Admin | Mice[1] Female SCID mice bearing RS4;11 xenograft tumors were dosed with a single intravenous dose of QCA570 (compound 35) at 5 mg/kg[1]. |
| References |
| Molecular Formula | C39H33N7O4S |
|---|---|
| Molecular Weight | 695.798 |
| Hazard Codes | Xi |
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