DC Chemicals Limited
China
Product Name: Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate)
Price: $1900.0/100mg $3800.0/250mg $7600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

60789-62-0

60789-62-0 structure

60789-62-0 structure

Name: Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate)
Chemical Name: Clocapramine hydrochloride hydrate
CAS Number: 60789-62-0
Molecular Formula: C₂₈H₄₁Cl₃N₄O₂
Molecular Weight: 572.010
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2019-01-20 17:51:43
Modify Date: 2024-01-12 19:03:41
Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors.

Name	Clocapramine hydrochloride hydrate
Synonyms	[1,4'-Bipiperidine]-4'-carboxamide, 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-, hydrochloride, hydrate (1:2:1) 3-Chloro-5-(3-(4-piperidino-4- carbamoylpiperidino)propyl)-10,11-dihydro-5H- dibenz(b,f)azepine dihydrochloride monohydrate CLOCAPRAMINE DIHYDROCHLORIDE MONOHYDRATE 1'-[3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-1,4'-bipiperidine-4'-carboxamide dihydrochloride hydrate

Description	Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2 receptor, 5-HT2A receptor[1].
In Vivo	Clocapramine shows the lowest potency for D2-occupancy in vivo[1]. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D2 and frontal serotonin-5-HT2 receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT2 versus D2 receptors that fall between these two groups (ED50 of 14.5 mg/kg for D2, 4.9 mg/kg for 5-HT2)[2].
Animal Admin	Rats[2] Male Wistar rats (210 to 240 g) are housed in a temperature-controlled room with a 12-hour dark/light cycle (lights on at 8:30) and have free access to food and water. For competition studies, rats are pretreated with an intraperitoneal injection of varying doses of antipsychotic drugs or the same volume (0.21 to 0.24 mL) of the corresponding vehicle (DMSO), 10 minutes prior to the injection of [3H]-YM-09151-2 or [3H]-ketanserin[2].
References	[1]. Schotte A, et al. In vitro receptor binding and in vivo receptor occupancy in rat and guinea pig brain: risperidone compared with antipsychotics hitherto used. Jpn J Pharmacol. 1995 Dec;69(4):399-412. [2]. Sumiyoshi T, et al. Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy. Neuropsychopharmacology. 1995 Feb;12(1):57-64.

Molecular Formula	C₂₈H₄₁Cl₃N₄O₂
Molecular Weight	572.010
Exact Mass	570.229492