1638851-44-1
1638851-44-1 structure
- Name: HSK0935
- Chemical Name: HSK0935
- CAS Number: 1638851-44-1
- Molecular Formula: C22H25ClO7
- Molecular Weight: 436.88
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel SGLT
- Create Date: 2019-03-03 21:10:42
- Modify Date: 2024-01-02 09:07:07
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HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC50 of 1.3 nM. Antihyperglycemic activities[1].
| Name | HSK0935 |
|---|
| Description | HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC50 of 1.3 nM. Antihyperglycemic activities[1]. |
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| Related Catalog | |
| Target |
IC50: 1.3 nM (SGLT2)[1] |
| In Vitro | HSK0935 (Compound 31) demonstrates excellent hSGLT2 inhibition of 1.3 nM and a high hSGLT1/hSGLT2 selectivity of 843-fold[1]. |
| In Vivo | HSK0935 treatment (1, 3, and 10 mg/kg) shows robust urinary glucose excretion in Sprague−Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys[1]. HSK0935 is well tolerated up to 300 mg/kg without any mortality or severe untoward effects in a 28-day repeat-dose toxicology study in beagle dogs[1]. |
| References |
| Molecular Formula | C22H25ClO7 |
|---|---|
| Molecular Weight | 436.88 |