Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SPP86
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tom

DC Chemicals Limited
China
Product Name: SPP-86
Price: $800.0/100mg $1450.0/250mg $2600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

ShangHai DC Chemicals Co.,Ltd
China
Product Name: SPP-86
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

1357349-91-7

1357349-91-7 structure

1357349-91-7 structure

Name: SPP 86
Chemical Name: SPP-86
CAS Number: 1357349-91-7
Molecular Formula: C₁₆H₁₅N₅
Molecular Weight: 277.32
Catalog: Research Areas Cancer
Create Date: 2019-06-01 19:07:34
Modify Date: 2024-01-04 21:01:25
SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 selectively inhibits RET- induced ERK1/2 phosphorylation in thyroid cancer cell lines[1].

Name	SPP-86

Description	SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 selectively inhibits RET- induced ERK1/2 phosphorylation in thyroid cancer cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 8 nM (RET)[1].
References	[1]. Alao JP, et al. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014 Nov 20;14:853.

Molecular Formula	C₁₆H₁₅N₅
Molecular Weight	277.32

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport