1638646-27-1

1638646-27-1 structure

1638646-27-1 structure

Name: VU0453379
Chemical Name: VU0453379
CAS Number: 1638646-27-1
Molecular Formula: C₂₆H₃₄N₄O₂
Molecular Weight: 434.57
Catalog: Signaling Pathways GPCR/G Protein Glucagon Receptor
Create Date: 2019-06-29 22:10:04
Modify Date: 2024-04-01 19:13:40
VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM[1].

Name	VU0453379

Description	VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor
Target	EC50: 1.3 μM (GLP-1R)[1]
References	[1]. Morris LC, et al. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem. 2014 Dec 11;57(23):10192-7.

Molecular Formula	C₂₆H₃₄N₄O₂
Molecular Weight	434.57