385786-48-1

385786-48-1 structure

Name: Adaptaquin
Chemical Name: Adaptaquin
CAS Number: 385786-48-1
Molecular Formula: C₂₁H₁₆ClN₃O₂
Molecular Weight: 377.824
Create Date: 2019-09-07 09:48:16
Modify Date: 2024-01-11 12:23:01
Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PHD2), with an IC50 of 2 μM. Adaptaquin can inhibit lipid peroxidation and maintain mitochondrial function[1][2].

Name	Adaptaquin
Synonyms	MFCD02655485 8-Quinolinol, 7-[(4-chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]- 7-{(4-Chlorophenyl)[(3-hydroxypyridin-2-yl)amino]methyl}quinolin-8-ol 7-{(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl}-8-quinolinol

Description	Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PHD2), with an IC50 of 2 μM. Adaptaquin can inhibit lipid peroxidation and maintain mitochondrial function[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Metabolic Disease
Target	IC50: 2 μM (HIF-PHD2)[1]
References	[1]. Smirnova NA, et, al. Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chem Biol. 2010 Apr 23;17(4):380-91. [2]. Neitemeier S, et, al. Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 2016 May 5;7(5):e2214.