1597489-14-9
1597489-14-9 structure
- Name: ML401
- Chemical Name: ML401
- CAS Number: 1597489-14-9
- Molecular Formula: C20H20BrClN2O
- Molecular Weight: 419.74
- Catalog: Signaling Pathways GPCR/G Protein EBI2/GPR183
- Create Date: 2019-10-08 13:53:52
- Modify Date: 2024-01-11 02:39:35
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ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1].
| Name | ML401 |
|---|
| Description | ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 1.03 nM (EBI2)[1] |
| In Vitro | ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM)[1]. |
| In Vivo | ML401 shows very good stability in both human plasma and mouse plasma[1]. |
| References |
| Molecular Formula | C20H20BrClN2O |
|---|---|
| Molecular Weight | 419.74 |