1030123-90-0
1030123-90-0 structure
- Name: AEM1
- Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
- CAS Number: 1030123-90-0
- Molecular Formula: C20H14FN3O2S
- Molecular Weight: 379.408
- Catalog: Signaling Pathways NF-κB Keap1-Nrf2
- Create Date: 2020-01-18 23:40:42
- Modify Date: 2024-01-10 23:22:21
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NRF2 inhibitor AEM1 is a specific small molecule inhibitor of Nrf2 transcriptional activity in cancer cells, shows no activity against a panel of >100 kinases (including isoforms of PI3K, AKT, and PKC); broadly decreases the expression of Nrf2 controlled genes (HMOX1, GPX2), sensitizes A549 cells to various chemotherapeutic agents, and inhibits the growth of A549 cells in vitro and in vivo.
| Name | N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine |
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| Synonyms |
Thieno[2,3-d]pyrimidin-4-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-
MFCD15017488 N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine |
| Description | NRF2 inhibitor AEM1 is a specific small molecule inhibitor of Nrf2 transcriptional activity in cancer cells, shows no activity against a panel of >100 kinases (including isoforms of PI3K, AKT, and PKC); broadly decreases the expression of Nrf2 controlled genes (HMOX1, GPX2), sensitizes A549 cells to various chemotherapeutic agents, and inhibits the growth of A549 cells in vitro and in vivo. |
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| References | References 1. Bollong MJ, et al. ACS Chem Biol. 2015 Oct 16;10(10):2193-8. View Related Products by Target Keap1-Nrf2 |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 582.1±50.0 °C at 760 mmHg |
| Molecular Formula | C20H14FN3O2S |
| Molecular Weight | 379.408 |
| Flash Point | 305.9±30.1 °C |
| Exact Mass | 379.079071 |
| LogP | 5.06 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.726 |
| Hazard Codes | Xi |
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