1117684-36-2
1117684-36-2 structure
- Name: AZ 12799734
- Chemical Name: 4-({4-[(2,6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl}amino)benzenesulfonamide
- CAS Number: 1117684-36-2
- Molecular Formula: C18H18N4O3S
- Molecular Weight: 370.426
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2020-01-20 19:13:57
- Modify Date: 2024-04-02 05:05:36
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AZ12799734 (AZ-12799734) is a pan BMP/TGFβ inhibitor that potently inhibits ligand activated SMAD3/4 transcription with IC50 of 47 nM, inhibits receptor-mediated phosphorylation of SMAD1 by ALK1, BMPR1A and BMPR1B and phosphorylation of SMAD2 by ALK4, TGFBR1 and ALK7; inhibits TGFβ-induced migration in HaCaT cells.
| Name | 4-({4-[(2,6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl}amino)benzenesulfonamide |
|---|---|
| Synonyms |
4-({4-[(2,6-Dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide
Benzenesulfonamide, 4-[[4-[(2,6-dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]- 4-({4-[(2,6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl}amino)benzenesulfonamide |
| Description | AZ12799734 (AZ-12799734) is a pan BMP/TGFβ inhibitor that potently inhibits ligand activated SMAD3/4 transcription with IC50 of 47 nM, inhibits receptor-mediated phosphorylation of SMAD1 by ALK1, BMPR1A and BMPR1B and phosphorylation of SMAD2 by ALK4, TGFBR1 and ALK7; inhibits TGFβ-induced migration in HaCaT cells. |
|---|---|
| References | References 1. Spender LC, et al. Mol Pharmacol. 2018 Nov 20. pii: mol.118.112946. doi: 10.1124/mol.118.112946. 2. Goldberg FW, et al. J Med Chem. 2009 Dec 10;52(23):7901-5. View Related Products by Target TGF beta Receptor (TGFBR) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 554.0±60.0 °C at 760 mmHg |
| Molecular Formula | C18H18N4O3S |
| Molecular Weight | 370.426 |
| Flash Point | 288.9±32.9 °C |
| Exact Mass | 370.109955 |
| LogP | 3.91 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.641 |