1227067-71-1

1227067-71-1 structure

Name: AMG 580
Chemical Name: 1-(4-{3-[4-(1H-Benzimidazol-2-ylcarbonyl)phenoxy]-2-pyrazinyl}-1-piperidinyl)-2-fluoro-1-propanone
CAS Number: 1227067-71-1
Molecular Formula: C₂₆H₂₄FN₅O₃
Molecular Weight: 473.499
Create Date: 2020-01-11 17:58:50
Modify Date: 2024-04-05 17:31:44
AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM; displays no activity against PED isoforms at 30 uM; is suitable as a tracer for lead optimization to determine target coverage by novel PDE10A inhibitors, shows potential imaging biomarker for mapping PDE10A distribution and ensuring target coverage by therapeutic PDE10A inhibitors in clinical studies.

Name	1-(4-{3-[4-(1H-Benzimidazol-2-ylcarbonyl)phenoxy]-2-pyrazinyl}-1-piperidinyl)-2-fluoro-1-propanone
Synonyms	1-(4-{3-[4-(1H-Benzimidazol-2-ylcarbonyl)phenoxy]-2-pyrazinyl}-1-piperidinyl)-2-fluoro-1-propanone 1-Propanone, 1-[4-[3-[4-(1H-benzimidazol-2-ylcarbonyl)phenoxy]-2-pyrazinyl]-1-piperidinyl]-2-fluoro- MFCD30470997

Description	AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM; displays no activity against PED isoforms at 30 uM; is suitable as a tracer for lead optimization to determine target coverage by novel PDE10A inhibitors, shows potential imaging biomarker for mapping PDE10A distribution and ensuring target coverage by therapeutic PDE10A inhibitors in clinical studies.
References	References 1. Chen H, et al. J Pharmacol Exp Ther. 2015 Feb;352(2):327-37. 2. Hu E, et al. ACS Med Chem Lett. 2016 May 19;7(7):719-23. 3. Hwang DR, et al. Nucl Med Biol. 2015 Aug;42(8):654-63. View Related Products by Target Phosphodiesterase (PDE)