1248581-07-8

1248581-07-8 structure

Name: PTC725
Chemical Name: 6-[3-Cyano-6-ethyl-5-fluoro-1-(2-pyrimidinyl)-1H-indol-2-yl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]-3-pyridinesulfonamide
CAS Number: 1248581-07-8
Molecular Formula: C₂₃H₁₈F₄N₆O₂S
Molecular Weight: 518.487
Catalog: Signaling Pathways Anti-infection HCV
Create Date: 2020-01-12 14:32:49
Modify Date: 2024-09-18 21:50:12
PTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM; displays a selectivity index of >5,000 with respect to cellular GAPDH, and >1,000-fold selectivity window with respect to cytotoxicity; retains fully activity against HCV replicon mutants that are resistant to inhibitors of NS3 protease and NS5B polymerase, demonstrates synergistic affect in combination with alpha interferon in vivo.

Name	6-[3-Cyano-6-ethyl-5-fluoro-1-(2-pyrimidinyl)-1H-indol-2-yl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]-3-pyridinesulfonamide
Synonyms	3-Pyridinesulfonamide, 6-[3-cyano-6-ethyl-5-fluoro-1-(2-pyrimidinyl)-1H-indol-2-yl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]- 6-[3-Cyano-6-ethyl-5-fluoro-1-(2-pyrimidinyl)-1H-indol-2-yl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]-3-pyridinesulfonamide

Description	PTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM; displays a selectivity index of >5,000 with respect to cellular GAPDH, and >1,000-fold selectivity window with respect to cytotoxicity; retains fully activity against HCV replicon mutants that are resistant to inhibitors of NS3 protease and NS5B polymerase, demonstrates synergistic affect in combination with alpha interferon in vivo.
References	References 1. Gu Z, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3250-61. 2. Zhang N, et al. J Med Chem. 2014 Mar 13;57(5):2121-35. 3. Graci JD, et al. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7060-7066. View Related Products by Target HCV