1334165-90-0

1334165-90-0 structure

Name: JNJ-42314415
Chemical Name: 3-[6-(2-Methoxyethyl)-3-pyridinyl]-2-methyl-8-(4-morpholinyl)imidazo[1,2-a]pyrazine
CAS Number: 1334165-90-0
Molecular Formula: C₁₉H₂₃N₅O₂
Molecular Weight: 353.418
Create Date: 2020-01-12 01:10:51
Modify Date: 2024-01-31 17:51:39
JNJ-42314415(JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A; inhibits rPDE10A with Ki of 64 nM, >100-fold selectivity over the other 10 PDE families; blocks conditioned avoidance behavior and behaviors induced by nondopaminergic stimulants (phencyclidine, scopolamine) more efficiently than D(2) receptor blockers, with less pronounced catalepsy; shows antipsychotic activity with an improved side-effect profile in vivo.

Name	3-[6-(2-Methoxyethyl)-3-pyridinyl]-2-methyl-8-(4-morpholinyl)imidazo[1,2-a]pyrazine
Synonyms	Imidazo[1,2-a]pyrazine, 3-[6-(2-methoxyethyl)-3-pyridinyl]-2-methyl-8-(4-morpholinyl)- 3-[6-(2-Methoxyethyl)-3-pyridinyl]-2-methyl-8-(4-morpholinyl)imidazo[1,2-a]pyrazine

Description	JNJ-42314415(JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A; inhibits rPDE10A with Ki of 64 nM, >100-fold selectivity over the other 10 PDE families; blocks conditioned avoidance behavior and behaviors induced by nondopaminergic stimulants (phencyclidine, scopolamine) more efficiently than D(2) receptor blockers, with less pronounced catalepsy; shows antipsychotic activity with an improved side-effect profile in vivo.
References	References 1. Megens AA, et al. J Pharmacol Exp Ther. 2014 Apr;349(1):138-54. View Related Products by Target Phosphodiesterase (PDE)