1353384-61-8

1353384-61-8 structure

Name: AQ-101
Chemical Name: 2-Chloro-N-(4,5-dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenyl)acetamide
CAS Number: 1353384-61-8
Molecular Formula: C₁₆H₁₀ClNO₅
Molecular Weight: 331.707
Create Date: 2020-01-12 04:51:13
Modify Date: 2024-01-11 14:57:48
AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53; induces apoptosis of acute lymphoblastic leukemia (ALL) especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo; inhibits development of ALL in nude or SCID mice with a human ALL xenograft.

Name	2-Chloro-N-(4,5-dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenyl)acetamide
Synonyms	2-Chloro-N-(4,5-dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenyl)acetamide Acetamide, 2-chloro-N-(9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenyl)-

Description	AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53; induces apoptosis of acute lymphoblastic leukemia (ALL) especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo; inhibits development of ALL in nude or SCID mice with a human ALL xenograft.
References	References 1. Gu L, et al. Mol Cancer Ther. 2018 Feb;17(2):497-507. View Related Products by Target MDM2-p53